diff --git a/devices/src/virtio/interrupt.rs b/devices/src/virtio/interrupt.rs
index 0665b3fc99..f808d84738 100644
--- a/devices/src/virtio/interrupt.rs
+++ b/devices/src/virtio/interrupt.rs
@@ -14,6 +14,7 @@ pub struct Interrupt {
     interrupt_evt: EventFd,
     interrupt_resample_evt: EventFd,
     msix_config: Option<Arc<Mutex<MsixConfig>>>,
+    config_msix_vector: u16,
 }
 
 impl Interrupt {
@@ -22,12 +23,14 @@ impl Interrupt {
         interrupt_evt: EventFd,
         interrupt_resample_evt: EventFd,
         msix_config: Option<Arc<Mutex<MsixConfig>>>,
+        config_msix_vector: u16,
     ) -> Interrupt {
         Interrupt {
             interrupt_status,
             interrupt_evt,
             interrupt_resample_evt,
             msix_config,
+            config_msix_vector,
         }
     }
 
@@ -64,12 +67,9 @@ impl Interrupt {
         self.signal(vector, INTERRUPT_STATUS_USED_RING)
     }
 
-    /// Notification of Device Configuration Changes
-    /// Set BIT1 in ISR and write to irqfd
+    /// Notify the driver that the device configuration has changed.
     pub fn signal_config_changed(&self) {
-        self.interrupt_status
-            .fetch_or(INTERRUPT_STATUS_CONFIG_CHANGED as usize, Ordering::SeqCst);
-        self.interrupt_evt.write(1).unwrap();
+        self.signal(self.config_msix_vector, INTERRUPT_STATUS_CONFIG_CHANGED)
     }
 
     /// Handle interrupt resampling event
diff --git a/devices/src/virtio/vhost/net.rs b/devices/src/virtio/vhost/net.rs
index 1196200a23..8462da58ce 100644
--- a/devices/src/virtio/vhost/net.rs
+++ b/devices/src/virtio/vhost/net.rs
@@ -233,6 +233,7 @@ where
 #[cfg(test)]
 pub mod tests {
     use super::*;
+    use crate::virtio::VIRTIO_MSI_NO_VECTOR;
     use net_util::fakes::FakeTap;
     use std::result;
     use std::sync::atomic::AtomicUsize;
@@ -295,6 +296,7 @@ pub mod tests {
                 EventFd::new().unwrap(),
                 EventFd::new().unwrap(),
                 None,
+                VIRTIO_MSI_NO_VECTOR,
             ),
             vec![Queue::new(1)],
             vec![EventFd::new().unwrap()],
diff --git a/devices/src/virtio/virtio_pci_device.rs b/devices/src/virtio/virtio_pci_device.rs
index c535ab5f30..b79a98a3a9 100644
--- a/devices/src/virtio/virtio_pci_device.rs
+++ b/devices/src/virtio/virtio_pci_device.rs
@@ -618,6 +618,7 @@ impl PciDevice for VirtioPciDevice {
                             interrupt_evt,
                             interrupt_resample_evt,
                             msix_config,
+                            self.common_config.msix_config,
                         );
 
                         self.device.activate(
diff --git a/fuzz/block_fuzzer.rs b/fuzz/block_fuzzer.rs
index 1730d49d6f..ec103bb937 100644
--- a/fuzz/block_fuzzer.rs
+++ b/fuzz/block_fuzzer.rs
@@ -88,7 +88,8 @@ fuzz_target!(|bytes| {
             Arc::new(AtomicUsize::new(0)),
             EventFd::new().unwrap(),
             EventFd::new().unwrap(),
-            None, // msix_config
+            None,   // msix_config
+            0xFFFF, // VIRTIO_MSI_NO_VECTOR
         ),
         vec![q],
         queue_evts,